Natamycin
Natamycin
Definition
A polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.
Also known as 16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure, Delvolan, Myprozine, Natacyn, NATAMYCIN, Pimaricin, Synogil — per NCIT
Also identified as
- ATC A01AB10 per RXNORM
- ATC A07AA03 per RXNORM
- ATC D01AA02 per RXNORM
- ATC G01AA02 per RXNORM
- ATC S01AA10 per RXNORM
- NCIT NCIT:C47634 per NCIT
- SCTID 34462007 per RXNORM
- SCTID 372712006 per RXNORM
- UNII 8O0C852CPO per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Aspergillosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Blastomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Blepharitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Coccidioidomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Conjunctivitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Cryptococcosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Fungal infection of eye | may treat | MEDRT · Public domain (U.S. Government work) |
| Histoplasmosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Keratitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Microsporidiosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Sporotrichosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Trichomonas vaginitis urogenital infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Conjunctiva | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cornea | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Female reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ocular adnexa | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.