Niacinamide
Niacinamide
Definition
The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.
Also known as 3-Pyridinecarboxamide, NIACINAMIDE, Nicamid, Nicosedine, Nicotinamide, Nicotinamidum, Nicotinic Acid Amide, Nicotylamide, Pellagra-Preventing Factor, Vitamin PP — per NCIT
Also identified as
- ATC A11HA01 per RXNORM
- NCIT NCIT:C2327 per NCIT
- SCTID 173196005 per RXNORM
- UNII 25X51I8RD4 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Coronary artery disorder | may prevent | MEDRT · Public domain (U.S. Government work) |
| Pellagra | may prevent | MEDRT · Public domain (U.S. Government work) |
| Hypertriglyceridemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Pellagra | may treat | MEDRT · Public domain (U.S. Government work) |
| Peripheral vascular disease | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.