Nifurtimox

ATC Code P01CC01

Nifurtimox

Definition

A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.

Also known as 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide, BAY 2502, BAYER 2502, Lampit, NIFURTIMOX — per NCIT

Also identified as