Nimodipine

Definition

A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.

Also known as NIMO, NIMODIPINE, Nimotop — per NCIT

Also identified as

• ATC C08CA06 per RXNORM
• NCIT NCIT:C692 per NCIT
• SCTID 387502003 per RXNORM
• SCTID 87285001 per RXNORM
• UNII 57WA9QZ5WH per RXNORM

Indications