Nortriptyline
ATC Code
N06AA10
Nortriptyline
Definition
A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.
Also known as NORTRIPTYLINE — per NCIT
Also identified as
- ATC N06AA10 per RXNORM
- NCIT NCIT:C62060 per NCIT
- SCTID 13432000 per RXNORM
- SCTID 372652004 per RXNORM
- UNII BL03SY4LXB per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Attention deficit hyperactivity disorder, inattentive type | may treat | MEDRT · Public domain (U.S. Government work) |
| Depressive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Enuresis | may treat | MEDRT · Public domain (U.S. Government work) |