Paromomycin

Definition

An aminoglycoside antibiotic derived from Streptomyces rimosus var. paromomycinus, with amebicidal and antibacterial activity. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation, thereby leading to inhibition of protein synthesis followed by cell death.

Also known as Antibiotic 503-3, Antibiotic SF 767B, Estomycin, Gabromycin, Hydroxymycin, Monomycin A, Neomycin E, O-2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4)-O-(O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-Beta-D-Ribofuranosyl-(1->5))-2-Deoxy-D-Streptamine, O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-O-Beta-D-Ribofuranosyl-(1->5)-O-(2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4))-2-Deoxystreptamine, PAROMOMYCIN, Paromomycin I, Paucimycin, Quintomycin C, R-400 — per NCIT

Also identified as

• ATC A07AA06 per RXNORM
• NCIT NCIT:C61878 per NCIT
• SCTID 370323004 per RXNORM
• SCTID 38044001 per RXNORM
• UNII 61JJC8N5ZK per RXNORM

Indications