Pentoxifylline
Pentoxifylline
Definition
A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.
Also known as 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, Oxpentifylline, PENTOXIFYLLINE, Pentoxyphylline, PTX, Trental — per NCIT
Also identified as
- ATC C04AD03 per RXNORM
- NCIT NCIT:C733 per NCIT
- SCTID 387522004 per RXNORM
- SCTID 91376007 per RXNORM
- UNII SD6QCT3TSU per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Brain ischemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Cerebral malaria | may treat | MEDRT · Public domain (U.S. Government work) |
| Diabetic neuropathy | may treat | MEDRT · Public domain (U.S. Government work) |
| Diabetic peripheral angiopathy | may treat | MEDRT · Public domain (U.S. Government work) |
| Intermittent vascular claudication | may treat | MEDRT · Public domain (U.S. Government work) |
| Stroke | may treat | MEDRT · Public domain (U.S. Government work) |
| Thrombotic disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Vasculitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Vasculogenic impotence | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.