Phenoxybenzamine
ATC Code
C04AX02
Phenoxybenzamine
Definition
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
Also known as N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine, PHENOXYBENZAMINE — per NCIT
Also identified as
- ATC C04AX02 per RXNORM
- NCIT NCIT:C62065 per NCIT
- SCTID 372838003 per RXNORM
- SCTID 74771007 per RXNORM
- UNII 0TTZ664R7Z per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bladder neck obstruction | may treat | MEDRT · Public domain (U.S. Government work) |
| Malignant hypertension | may treat | MEDRT · Public domain (U.S. Government work) |
| Pheochromocytoma | may treat | MEDRT · Public domain (U.S. Government work) |