Phentolamine

Definition

A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.

Also known as 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline, PHENTOLAMINE — per NCIT

Also identified as

• ATC C04AB01 per RXNORM
• ATC V03AB36 per RXNORM
• NCIT NCIT:C62066 per NCIT
• SCTID 372863003 per RXNORM
• SCTID 82165003 per RXNORM
• UNII Z468598HBV per RXNORM

Indications