Alteplase
Alteplase
Definition
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.
Also known as Activase, ALTEPLASE, Plasminogen Activator (Human Tissue-Type Protein Moiety), r-tPA, Recombinant Tissue Plasminogen Activator, rt-PA — per NCIT
Also identified as
- ATC B01AD02 per RXNORM
- ATC S01XA13 per RXNORM
- NCIT NCIT:C39607 per NCIT
- SCTID 108997009 per RXNORM
- SCTID 27638005 per RXNORM
- SCTID 37411004 per RXNORM
- SCTID 387152000 per RXNORM
- UNII 1RXS4UE564 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Myocardial infarction | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary embolism | may treat | MEDRT · Public domain (U.S. Government work) |
| Stroke | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculature | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Myocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.