Fluconazole
Fluconazole
Definition
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
Also known as alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol, Diflucan, FLUCONAZOLE — per NCIT
Also identified as
- ATC D01AC per NCIT
- ATC J02AC per NCIT
- NCIT NCIT:C500 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Blastomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Coccidioidomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Cryptococcal meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Histoplasmosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Oral candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pneumonia | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Vulvovaginal candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Meninx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.