Primidone

ATC Code N03AA03

Primidone

Definition

An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.

Also known as 2-Deoxyphenobarbital, 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-, Myidone, Mysedon, Mysoline, Apo-Primidone, Neurosyn, Primaclone, PRIMIDONE — per NCIT

Also identified as

Indications

Disease Relation Source
Epilepsy with generalized tonic-clonic seizures may treat MEDRT · Public domain (U.S. Government work)
Focal epilepsy may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Brain may treat a disease of this organ DERIVED · CC BY 4.0
Central nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Nervous system may treat a disease of this organ DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.