Probenecid
Probenecid
Definition
A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.
Also known as Benemid, PROB, PROBENECID, SK-Probenecid — per NCIT
Also identified as
- ATC M04AB01 per RXNORM
- NCIT NCIT:C772 per NCIT
- SCTID 387365004 per RXNORM
- SCTID 66094001 per RXNORM
- UNII PO572Z7917 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Gonorrhea | may treat | MEDRT · Public domain (U.S. Government work) |
| Gout | may treat | MEDRT · Public domain (U.S. Government work) |
| Neurosyphilis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.