Procarbazine

Definition

A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.

Also known as Benzethyzin, Ibenzmethyzin, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide, N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide, N-Methylhydrazine, p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide, Procarbazin, PROCARBAZINE — per NCIT

Also identified as

• ATC L01XB01 per RXNORM
• NCIT NCIT:C62072 per NCIT
• SCTID 10174003 per RXNORM
• SCTID 387474003 per RXNORM
• SCTID 81583003 per RXNORM
• UNII 35S93Y190K per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.