Itraconazole
ATC Code
J02AC02
Itraconazole
Definition
A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04)
Also known as (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one, ITRACONAZOLE, Lozanoc, Oriconazole, R 51,211, Sporanox — per NCIT
Also identified as
- ATC J02AC per NCIT
- NCIT NCIT:C1138 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Aspergillosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Blastomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Coccidioidomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Cryptococcosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Histoplasmosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Leishmaniasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Neutropenia | may treat | MEDRT · Public domain (U.S. Government work) |
| Oral candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Paracoccidioidomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Sporotrichosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Tinea unguium | may treat | MEDRT · Public domain (U.S. Government work) |
| Vulvovaginal candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Zygomycosis | may treat | MEDRT · Public domain (U.S. Government work) |