Protamine Sulfate

Definition

The sulfate salt form of protamine, a highly basic protein rich in arginine and a heparin antagonist, that can be used to neutralize heparin-induced anticoagulation. Upon intravenous administration, the cationic hydrogenated protamine reacts with anionic heparin to form an inactive salt aggregate, which has no anticoagulant activity. Protamine, when administered alone in the absence of heparin, is a weak anticoagulant.

Also known as PROTAMINE SULFATE, Protamine Sulphate — per NCIT

Also identified as

• NCIT NCIT:C84123 per NCIT
• SCTID 64520006 per RXNORM
• UNII 0DE9724IHC per RXNORM