Pyrimethamine
ATC Code
P01BD01
Pyrimethamine
Definition
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)
Also known as Daraprim, PYRIMETHAMINE — per NCIT
Also identified as
- ATC P01BD01 per RXNORM
- NCIT NCIT:C788 per NCIT
- SCTID 373769001 per RXNORM
- SCTID 59589008 per RXNORM
- UNII Z3614QOX8W per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Malaria | may prevent | MEDRT · Public domain (U.S. Government work) |
| Plasmodium falciparum malaria | may treat | MEDRT · Public domain (U.S. Government work) |
| Toxoplasmosis | may treat | MEDRT · Public domain (U.S. Government work) |