Ketoconazole

ATC Code J02AB02

Ketoconazole

Definition

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

Also known as Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, Fungarest, Fungoral, KETOCONAZOLE, Ketoderm, Ketoisdin, Nizoral, Orifungal M, Panfungol, R-41400, Xolegel — per NCIT

Also identified as

Indications

Disease Relation Source
Fungal infectious disease may prevent MEDRT · Public domain (U.S. Government work)
Acanthamoeba keratitis may treat MEDRT · Public domain (U.S. Government work)
Blastomycosis may treat MEDRT · Public domain (U.S. Government work)
Coccidioidomycosis may treat MEDRT · Public domain (U.S. Government work)
Cutaneous candidiasis may treat MEDRT · Public domain (U.S. Government work)
Fungal infectious disease may treat MEDRT · Public domain (U.S. Government work)
Histoplasmosis may treat MEDRT · Public domain (U.S. Government work)
Leishmaniasis may treat MEDRT · Public domain (U.S. Government work)
Oral candidiasis may treat MEDRT · Public domain (U.S. Government work)
Paracoccidioidomycosis may treat MEDRT · Public domain (U.S. Government work)
Pityriasis versicolor may treat MEDRT · Public domain (U.S. Government work)
Seborrheic dermatitis may treat MEDRT · Public domain (U.S. Government work)
Tinea pedis may treat MEDRT · Public domain (U.S. Government work)
Vulvovaginal candidiasis may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Camera-type eye may treat a disease of this organ DERIVED · CC BY 4.0
Cornea may treat a disease of this organ DERIVED · CC BY 4.0
Skin of body may treat a disease of this organ DERIVED · CC BY 4.0

3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.