Quinine
ATC Code
P01BC01
Quinine
Definition
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Also known as (-)-Quinine, QUIN, QUININE — per NCIT
Also identified as
- ATC P01BC01 per RXNORM
- NCIT NCIT:C794 per NCIT
- SCTID 373497008 per RXNORM
- SCTID 47065008 per RXNORM
- UNII A7V27PHC7A per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Babesiosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Plasmodium falciparum malaria | may treat | MEDRT · Public domain (U.S. Government work) |