Scopolamine
Scopolamine
Definition
A tropane alkaloid derived from plants of the nightshade family (Solanaceae), specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. Structurally similar to acetylcholine, scopolamine antagonizes acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. The agent is used to cause mydriasis, cycloplegia, to control the secretion of saliva and gastric acid, to slow gut motility, and prevent vomiting.
Also known as 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate(ester), 6,7-Epoxytropine Tropate, 6beta,7beta-Epoxy-3alpha-tropanyl S-(-)-tropate, Atrochin, Benzeneacetic Acid, alpha-(hydroxymethyl)-,(1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester,(alphaS)-, Epoxytropine Tropate, Hyoscine, Scopoderm, SCOPOLAMINE, Transderm Scop — per NCIT
Also identified as
- ATC A04AD01 per RXNORM
- ATC N05CM05 per RXNORM
- ATC S01FA02 per RXNORM
- NCIT NCIT:C47712 per NCIT
- SCTID 387409009 per RXNORM
- SCTID 72870001 per RXNORM
- UNII DL48G20X8X per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Motion sickness | may prevent | MEDRT · Public domain (U.S. Government work) |
| Colonic disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Diverticulitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Dysentery | may treat | MEDRT · Public domain (U.S. Government work) |
| Facial paralysis | may treat | MEDRT · Public domain (U.S. Government work) |
| Iridocyclitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Postencephalitic Parkinson disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Vasomotor rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Uvea | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.