Amphotericin B

ATC Code J02AA01

Amphotericin B

Definition

A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

Also known as AmB, Amphocil, Amphotec, AMPHOTERICIN B — per NCIT

Also identified as

Indications

Disease Relation Source
Fungal infectious disease may prevent MEDRT · Public domain (U.S. Government work)
Aspergillosis may treat MEDRT · Public domain (U.S. Government work)
Blastomycosis may treat MEDRT · Public domain (U.S. Government work)
Candidiasis may treat MEDRT · Public domain (U.S. Government work)
Coccidioidomycosis may treat MEDRT · Public domain (U.S. Government work)
Cryptococcal meningitis may treat MEDRT · Public domain (U.S. Government work)
Cutaneous candidiasis may treat MEDRT · Public domain (U.S. Government work)
Cystitis may treat MEDRT · Public domain (U.S. Government work)
Histoplasmosis may treat MEDRT · Public domain (U.S. Government work)
Neutropenia may treat MEDRT · Public domain (U.S. Government work)
Paracoccidioidomycosis may treat MEDRT · Public domain (U.S. Government work)
Peritonitis may treat MEDRT · Public domain (U.S. Government work)
Sporotrichosis may treat MEDRT · Public domain (U.S. Government work)
Urinary tract infection may treat MEDRT · Public domain (U.S. Government work)
Visceral leishmaniasis may treat MEDRT · Public domain (U.S. Government work)
Zygomycosis may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Central nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Genitourinary system may treat a disease of this organ DERIVED · CC BY 4.0
Meninx may treat a disease of this organ DERIVED · CC BY 4.0
Nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Renal system may treat a disease of this organ DERIVED · CC BY 4.0
Urinary bladder may treat a disease of this organ DERIVED · CC BY 4.0

6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.