Streptomycin
Streptomycin
Definition
An aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, streptomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.
Also known as STREPTOMYCIN — per NCIT
Also identified as
- ATC A07AA04 per RXNORM
- ATC J01GA01 per RXNORM
- NCIT NCIT:C61952 per NCIT
- SCTID 387223008 per RXNORM
- SCTID 40877002 per RXNORM
- UNII Y45QSO73OB per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial endocarditis | may treat | MEDRT · Public domain (U.S. Government work) |
| Brucellosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Chancroid | may treat | MEDRT · Public domain (U.S. Government work) |
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Granuloma inguinale | may treat | MEDRT · Public domain (U.S. Government work) |
| Klebsiella infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Mycobacterial infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Plague | may treat | MEDRT · Public domain (U.S. Government work) |
| Proteus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Tularemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.