Sulbactam

Definition

A semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.

Also known as (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid 4,4-dioxide, CP 45899, SULBACTAM — per NCIT

Also identified as

• ATC J01CG01 per RXNORM
• NCIT NCIT:C61957 per NCIT
• SCTID 398916003 per RXNORM
• SCTID 96008003 per RXNORM
• UNII S4TF6I2330 per RXNORM

Indications