Sulindac
Sulindac
Definition
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
Also known as (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid, Aflodac, Algocetil, Apo-Sulin, Arthrocine, Artribid, cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid, Citireuma, Clinoril, Clisundac, Imbaral, MK-231, Novo-Sundac, Reumofil, Reumyl, Sudac, SULINDAC, Sulindac Sulfoxide, Sulinol, Sulreuma — per NCIT
Also identified as
- ATC M01AB02 per RXNORM
- NCIT NCIT:C850 per NCIT
- SCTID 387513000 per RXNORM
- SCTID 89505005 per RXNORM
- UNII 184SNS8VUH per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Ankylosing spondylitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bursitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Disease of the tendon | may treat | MEDRT · Public domain (U.S. Government work) |
| Osteoarthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.