Thiotepa

Definition

A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.

Also known as 1,1',1''-Phosphinothioyldynetrisaziridine, 1,1',1''-Phosphinothioylidynetrisaziridine, 1,1',1"-phosphinothioylidynetrisaziridine, Girostan, N,N', N''-Triethylenethiophosphoramide, N,N',N''-triethylenethiophosphoramide, Oncotiotepa, SH 105, SH-105, SH105, STEPA, Tepadina, Tepylute, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoamide, Thiophosphoramide, Thioplex, Thiotef, THIOTEPA, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312 — per NCIT

Also identified as

• ATC L01AC01 per RXNORM
• NCIT NCIT:C875 per NCIT
• SCTID 387508004 per RXNORM
• SCTID 88997008 per RXNORM
• UNII 905Z5W3GKH per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.