Thioguanine

Definition

A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)

Also known as 2-Amino 6MP, 2-Amino-1,7-dihydro-6H-purine-6-thione, 2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol, 2-Aminopurin-6-thiol, 2-Aminopurine-6-thiol, 2-Aminopurine-6-thiol Hemihydrate, 2-Aminopurine-6(1H)-thione, 2-Mercapto-6-aminopurine, 6 Mercaptoguanine, 6 Thioguanine, 6-Amino-2-mercaptopurine, 6-Mercapto-2-aminopurine, 6-Mercaptoguanine, 6-TG, 6-Thioguanine, 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI), BW 5071, Lanvis, Tabloid, THIOGUANINE, Thioguanine Hemihydrate, Thioguanine Hydrate, Tioguanin, Tioguanine, Wellcome U3B, WR-1141, X 27 — per NCIT

Also identified as

• ATC L01BB03 per RXNORM
• NCIT NCIT:C876 per NCIT
• SCTID 387407006 per RXNORM
• SCTID 72623000 per RXNORM
• UNII FTK8U1GZNX per RXNORM

Indications

Organ Effects

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