Tobramycin
Tobramycin
Definition
An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.
Also known as TOBRAMYCIN — per NCIT
Also identified as
- ATC J01GB01 per RXNORM
- ATC S01AA12 per RXNORM
- NCIT NCIT:C62082 per NCIT
- SCTID 373548001 per RXNORM
- SCTID 89695009 per RXNORM
- UNII VZ8RRZ51VK per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Central nervous system infectious disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Pseudomonas infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Respiratory tract infectious disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Skin disorder caused by infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.