Tolnaftate

Definition

A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.

Also known as Absorbine, Aftate, Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester, Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester, Desenex, Focusan, Genaspor, NP 27, Tinactin, TOLNAFTATE, Tolsanil — per NCIT

Also identified as

• ATC D01AE18 per RXNORM
• NCIT NCIT:C47763 per NCIT
• SCTID 38166006 per RXNORM
• SCTID 387204001 per RXNORM
• UNII 06KB629TKV per RXNORM

Indications