Tranexamic Acid

Definition

A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action.

Also known as Amixam, Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, trans-, Cyclokapron, Cyklokapron, Hemostan, Lysteda, Prexam, TRANEXAMIC ACID, Tranhexamic Acid, Tranofast — per NCIT

Also identified as

• ATC B02AA02 per RXNORM
• NCIT NCIT:C47765 per NCIT
• SCTID 109006003 per RXNORM
• SCTID 386960009 per RXNORM
• UNII 6T84R30KC1 per RXNORM

Indications