Triamterene

Definition

A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.

Also known as 6-Phenyl-2,4,7-pteridinetriamine, 6-Phenyl-2,4,7-triaminopteridine, Dyrenium, TRIAMTERENE — per NCIT

Also identified as

• ATC C03DB02 per RXNORM
• NCIT NCIT:C29519 per NCIT
• SCTID 12512008 per RXNORM
• SCTID 387053007 per RXNORM
• UNII WS821Z52LQ per RXNORM

Indications