Triazolam

Definition

A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.

Also known as 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine, Clorazolam, Halcion, Novidorm, Songar, TRIAZOLAM, U 33030, U-33,030 — per NCIT

Also identified as

• ATC N05CD05 per RXNORM
• NCIT NCIT:C29520 per NCIT
• SCTID 111128007 per RXNORM
• SCTID 386984001 per RXNORM
• UNII 1HM943223R per RXNORM

Indications