Trifluoperazine

Definition

A phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium.

Also known as 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine, 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, TFP, TRIFLUOPERAZINE — per NCIT

Also identified as

• ATC N05AB06 per RXNORM
• NCIT NCIT:C62084 per NCIT
• SCTID 373524005 per RXNORM
• SCTID 71699007 per RXNORM
• UNII 214IZI85K3 per RXNORM

Indications