Liothyronine
Liothyronine
Definition
A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
Also known as L-Triiodothyronine, LIOTHYRONINE, Therapeutic T3, Triiodothyronine — per NCIT
Also identified as
- NCIT NCIT:C907 per NCIT
- SCTID 350358003 per RXNORM
- SCTID 61275002 per RXNORM
- UNII 06LU7C9H1V per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Goiter | may prevent | MEDRT · Public domain (U.S. Government work) |
| Hypothyroidism | may prevent | MEDRT · Public domain (U.S. Government work) |
| Autoimmune thyroid disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Goiter | may treat | MEDRT · Public domain (U.S. Government work) |
| Myxedema | may treat | MEDRT · Public domain (U.S. Government work) |
| Thyrotoxicosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Thyroid gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.