Alpha-Tocopherol

ATC Code A11HA03

Alpha-Tocopherol

Definition

The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.

Also known as .ALPHA.-TOCOPHEROL, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol, 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol, Alpha-Tocopherol — per NCIT

Also identified as

Indications

Disease Relation Source
Alzheimer's disease may prevent MEDRT · Public domain (U.S. Government work)
Bronchopulmonary dysplasia may prevent MEDRT · Public domain (U.S. Government work)
Drug-induced dyskinesia may prevent MEDRT · Public domain (U.S. Government work)
Hemolytic anemia may prevent MEDRT · Public domain (U.S. Government work)
Alzheimer's disease may treat MEDRT · Public domain (U.S. Government work)
Drug-induced dyskinesia may treat MEDRT · Public domain (U.S. Government work)
Hemolytic anemia may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Central nervous system may treat a disease of this organ DERIVED · CC BY 4.0
Nervous system may treat a disease of this organ DERIVED · CC BY 4.0

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.