Argatroban

Definition

A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited.

Also known as 1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid, ARGATROBAN, Argipidine, MD-805 — per NCIT

Also identified as

• ATC B01AE03 per RXNORM
• NCIT NCIT:C28833 per NCIT
• SCTID 116508003 per RXNORM
• SCTID 398738008 per RXNORM
• UNII IY90U61Z3S per RXNORM

Indications