Mirtazapine

Definition

A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.

Also known as MIRTAZAPINE, Remeron — per NCIT

Also identified as

• ATC N06AX11 per RXNORM
• NCIT NCIT:C29265 per NCIT
• SCTID 108430001 per RXNORM
• SCTID 386847004 per RXNORM
• UNII A051Q2099Q per RXNORM

Indications