Acitretin
Acitretin
Definition
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)
Also known as (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid, ACITRETIN, Etretin, Neotigason, Ro 10-1670, Ro-10-1670, Soriatane, Trimethylmethoxyphenyl-retinoic acid — per NCIT
Also identified as
- ATC D05BB02 per RXNORM
- NCIT NCIT:C985 per NCIT
- SCTID 108914001 per RXNORM
- SCTID 386938006 per RXNORM
- UNII LCH760E9T7 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Psoriasis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.