Lansoprazole
Lansoprazole
Definition
A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
Also known as LANSOPRAZOLE, Prevacid — per NCIT
Also identified as
- ATC A02BC03 per RXNORM
- NCIT NCIT:C29150 per NCIT
- SCTID 108666007 per RXNORM
- SCTID 386888004 per RXNORM
- UNII 0K5C5T2QPG per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Duodenal ulcer | may treat | MEDRT · Public domain (U.S. Government work) |
| Esophagitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastric ulcer | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastroesophageal reflux disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Helicobacter pylori infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Zollinger-Ellison syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Esophagus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Small intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Stomach | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Upper digestive tract | may treat a disease of this organ | DERIVED · CC BY 4.0 |
6 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.