Alfuzosin

Definition

A synthetic quinazoline compound with smooth muscle relaxing activity. Alfuzosin selectively binds to and antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (BPH) and prostate cancer. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance.

NCIT:C61627 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as (+/-)-N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide, ALFUZOSIN, N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide — per NCIT

Also identified as

ATC G04CA01 per RXNORM
NCIT NCIT:C61627 per NCIT
SCTID 349912006 per RXNORM
SCTID 395954002 per RXNORM
UNII 90347YTW5F per RXNORM

Indications

Disease	Relation	Source
Benign prostatic hyperplasia	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Genitourinary system	may treat a disease of this organ	DERIVED · CC BY 4.0
Male reproductive system	may treat a disease of this organ	DERIVED · CC BY 4.0
Prostate	may treat a disease of this organ	DERIVED · CC BY 4.0
Reproductive system	may treat a disease of this organ	DERIVED · CC BY 4.0

4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.