Benazepril
Benazepril
Definition
A carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Also known as BENAZEPRIL — per NCIT
Also identified as
- ATC C09AA07 per RXNORM
- NCIT NCIT:C61645 per NCIT
- SCTID 108572003 per RXNORM
- SCTID 372511001 per RXNORM
- UNII UDM7Q7QWP8 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Diabetic kidney disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Diabetic kidney disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Heart failure | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertensive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.