Butoconazole

Definition

A synthetic imidazole derivative with fungistatic properties. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

Also known as (+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole, BUTOCONAZOLE, RS 35887-10-3 — per NCIT

Also identified as

• ATC G01AF15 per RXNORM
• NCIT NCIT:C79927 per NCIT
• SCTID 372878005 per RXNORM
• SCTID 84844007 per RXNORM
• UNII 0Q771797PH per RXNORM

Indications