Cefepime

ATC Code J01DE01

Cefepime

Definition

A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Also known as CEFEPIME — per NCIT

Also identified as

Indications

Disease Relation Source
Acinetobacter infectious disease may treat MEDRT · Public domain (U.S. Government work)
Bacterial pneumonia may treat MEDRT · Public domain (U.S. Government work)
Bacteroides infectious disease may treat MEDRT · Public domain (U.S. Government work)
Escherichia coli infection may treat MEDRT · Public domain (U.S. Government work)
Haemophilus infectious disease may treat MEDRT · Public domain (U.S. Government work)
Klebsiella infectious disease may treat MEDRT · Public domain (U.S. Government work)
Neutropenia may treat MEDRT · Public domain (U.S. Government work)
Proteus infectious disease may treat MEDRT · Public domain (U.S. Government work)
Pseudomonas infection may treat MEDRT · Public domain (U.S. Government work)
Pyelonephritis may treat MEDRT · Public domain (U.S. Government work)
Skin disease caused by bacterial infection may treat MEDRT · Public domain (U.S. Government work)
Staphylococcal infection may treat MEDRT · Public domain (U.S. Government work)
Streptococcal infection may treat MEDRT · Public domain (U.S. Government work)
Urinary tract infection may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Adult mammalian kidney may treat a disease of this organ DERIVED · CC BY 4.0
Genitourinary system may treat a disease of this organ DERIVED · CC BY 4.0
Lungs may treat a disease of this organ DERIVED · CC BY 4.0
Renal system may treat a disease of this organ DERIVED · CC BY 4.0
Respiratory system may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.