Ciclopirox
Ciclopirox
Definition
A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
Also known as CICLOPIROX — per NCIT
Also identified as
- ATC D01AE14 per RXNORM
- ATC G01AX12 per RXNORM
- NCIT NCIT:C61677 per NCIT
- SCTID 372854000 per RXNORM
- SCTID 79736009 per RXNORM
- UNII 19W019ZDRJ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cutaneous candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pityriasis versicolor | may treat | MEDRT · Public domain (U.S. Government work) |
| Tinea pedis | may treat | MEDRT · Public domain (U.S. Government work) |
| Tinea unguium | may treat | MEDRT · Public domain (U.S. Government work) |