Clobazam
Clobazam
Definition
A 1,5-benzodiazepine and partial gamma-aminobutyric acid (GABA) receptor agonist, with anxiolytic, sedative, and anticonvulsant activities. Clobazam binds to a specific site, distinct from the inhibitory neurotransmitter GABA binding site, on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the opening of chloride-channels. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and a decrease in neuronal excitability.
Also known as CLOBAZAM, Frisium, Onfi, Urbanol — per NCIT
Also identified as
- ATC N05BA09 per RXNORM
- NCIT NCIT:C81615 per NCIT
- SCTID 387572002 per RXNORM
- SCTID 96236000 per RXNORM
- UNII 2MRO291B4U per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Lennox-Gastaut syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Visual epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.