Felbamate
Felbamate
Definition
A propanediol compound with anticonvulsant and antiepileptic properties. Although the exact mechanism of action is unknown, Felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex, thereby blocking the effects of the excitatory amino acids, suppressing neuronal firing, and preventing seizure activity. Felbamate also has weak inhibitory effects on gamma-aminobutyric acid (GABA) receptor binding sites which may contribute to its inhibitory effect on neuronal excitatory.
Also known as 2-Phenyl-1,3-propanediol Dicarbamate, Carbamic Acid, 2-phenyltrimethylene Ester, FELBAMATE, Felbatol — per NCIT
Also identified as
- ATC N03AX10 per RXNORM
- NCIT NCIT:C47530 per NCIT
- SCTID 371387009 per RXNORM
- SCTID 96194006 per RXNORM
- UNII X72RBB02N8 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Complex partial epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
| Lennox-Gastaut syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Visual epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.