Tinidazole
Tinidazole
Definition
A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.
Also known as Fasigyn, Simplotan, TDZ, Tindamax, TINIDAZOLE — per NCIT
Also identified as
- ATC G01AF per NCIT
- ATC J01XD per NCIT
- ATC P01AB per NCIT
- NCIT NCIT:C890 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Amebiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial vaginosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Giardiasis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Female reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.