Methylnaltrexone

Definition

A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.

Also known as 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium, METHYLNALTREXONE, Quaternary Ammonium Naltrexone — per NCIT

Also identified as

• NCIT NCIT:C48403 per NCIT
• SCTID 429838001 per RXNORM
• SCTID 431072004 per RXNORM
• UNII 0RK7M7IABE per RXNORM

Indications