Olsalazine
Olsalazine
Definition
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals.
Also known as 3,3'-Azobis[6-hydroxybenzoic Acid], 3,3'-Dicarboxy-4,4'-dihydroxyazobenzene, Azodisalicylate, C.I. Mordant Yellow 5, OLSALAZINE — per NCIT
Also identified as
- ATC A07EC03 per RXNORM
- NCIT NCIT:C1176 per NCIT
- SCTID 108673002 per RXNORM
- SCTID 386890003 per RXNORM
- UNII ULS5I8J03O per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Ulcerative colitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.