Lorazepam
Lorazepam
Definition
A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
Also known as 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one, Ativan, LORAZEPAM — per NCIT
Also identified as
- ATC N05BA per NCIT
- NCIT NCIT:C619 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Catatonia | may treat | MEDRT · Public domain (U.S. Government work) |
| Depressive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Focal epilepsy | may treat | MEDRT · Public domain (U.S. Government work) |
| Insomnia | may treat | MEDRT · Public domain (U.S. Government work) |
| Substance withdrawal syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Brain | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.