Oxiconazole

Definition

A broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.

Also known as OXICONAZOLE — per NCIT

Also identified as

• ATC D01AC11 per RXNORM
• ATC G01AF17 per RXNORM
• NCIT NCIT:C61869 per NCIT
• SCTID 372778004 per RXNORM
• SCTID 57263002 per RXNORM
• UNII C668Q9I33J per RXNORM

Indications